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New EuroClonality publication on 1-tube TRG assays, discontinuation of commercial TRG 2-tube assay
Production and sales of the EuroClonality/BIOMED-2 TRG tube A-B assays has been discontinued by Invivoscribe, as the Invivoscribe TRG2.0 assay (1-tube assay) is available since a couple of years. The Invivoscribe TRG2.0 assay performance has recently been evaluated in a multi-center study in comparison with the EuroClonality/BIOMED-2 TRG 2-tube assay as well as a new EuroClonality TRG 1-tube assay (Armand et al, HemaSphere 2019;3:e255). The latter was designed with the following specifications: (i) to regroup PCR products within a limited size range, (ii) to generate relatively short PCR products (<200 bp), (iii) to combine all primers within a single tube. Compared to the classical EuroClonality/BIOMED-2 TRG 2-tube assay, both 1-tube assays displayed fairly similar performances and demonstrated easier interpretation as well as a lower risk of false positives from minor peaks in dispersed repertoires. In addition, both assays generate smaller fragments, likely to be better adapted to analysis of formalin-fixed paraffin-embedded tissue samples.
New EuroClonality-NGS publications and SOPs
Three new manuscripts of the EuroClonality-NGS Working Group have been accepted in Leukemia. Two SOPs related to these publications are available in the protocols section of the EuroClonality website: “NGS-based clonality assessment of immunoglobulin gene rearrangements for the Ion Torrent platform” and “Two-step IG/TR NGS-based marker identification for the Illumina MiSeq platform”.
EQA 2019 registration
Registrations for the 2019 External Quality Assessment Scheme for IG/TR Clonality Testing in Suspected Lymphoproliferations/Lymphoma organized by the EuroClonality network, is open.
http://kras.eqascheme.org/info/public/static/euroclonality.xhtml
Recent activities
EuroClonality-NGS Consortium on Next-Generation Sequencing for IG / TR immunogenetic analysis
Agenda
Educational Workshop
EuroClonality/BIOMED-2:
“Clonality assessment in Pathology”
Workshop 2021: February
Nijmegen, the Netherlands
Interpretation Tables
Ig/TCR clonality interpretation and reporting tables in different languages.
| Language | Table |
| ENGLISH |  |
| GERMAN |  |
| FRENCH |  |
| DUTCH |  |
| SPANISH |  |
| PORTUGESE |  |
| ITALIAN |  |
| SWEDISH |  |
When using this Tables, please refer to www.euroclonality.org and to the original publication in which the English version of the Tables is published: Langerak, et all., Leukemia 2012;26:2159-2172
EuroClonality Board
Dr. Patricia Groenen, chair
Dr. Anton Langerak, treasurer
Prof. Dr. Frederic Davi, secretariat
Dr. Jose Cabeçadas
Dr. Paula Gameiro
Prof. Jacques J.M. van Dongen, founding chairman 1996-2011
Project manager EuroClonality
Bart Lubbers
Workshop secretariat
Jeanet Heijnen
workshop@euroclonality.org
Webmaster
Paul Rombout
contact
info@euroclonality.org
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